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A person online says they switched from tirzepatide (the active ingredient in Mounjaro) to a semaglutide product called Semavy because of price. They report losing 20 kg (about 44 lb) over nine months on tirzepatide. After switching, they started semaglutide at 1 mg and then 1.5 mg and say they felt nothing — no appetite suppression, no side effects, and no weight loss so far. They’re asking if others had the same experience or if some people don’t respond to semaglutide. Semaglutide is the drug behind brand names like Ozempic and Wegovy. In plain terms, it acts like a natural gut hormone that tells your brain you’re full and slows how fast your stomach empties, which usually lowers appetite and helps people eat less. It’s not the same as tirzepatide (Mounjaro), which hits two different gut hormone systems at once and often produces stronger appetite loss and weight loss. Semaglutide is typically given as a weekly injection and comes in different doses depending on whether it’s used for diabetes or weight management. What this post actually shows is one person’s experience — an anecdote, not a controlled study. They had a big, successful response to tirzepatide and then reported almost no effect after switching to semaglutide, even after increasing the dose a bit. Single reports like this can happen for several reasons: individual differences in biology, differences between the two drugs’ effects, a dosing or administration issue, or even a counterfeit or mishandled medication. The post doesn’t provide medical tests, timelines beyond a couple of weeks, or proof about the product’s authenticity, so it can’t tell us how common this is or what the real cause was. Why this matters: plenty of people are making switches between weight-loss drugs because of cost or availability. If someone stops getting results after switching, that’s important to know — it could mean one drug works much better for a particular person, or that there are problems with how the new medication is being stored, dosed, or even whether it’s genuine. Anyone taking these medicines should watch how their appetite, side effects, and weight change, and should tell their prescriber if a drug seems ineffective. Caveats and risks: personal reports can’t prove a drug is ineffective. Semaglutide can take time and may need gradual dose increases to reach the dose used for weight loss. Side effects can include nausea, stomach upset, and rarely more serious problems, and not everyone is a candidate for these drugs. There’s also a risk with buying cheaper alternatives or unverified sources — some products might be counterfeit or improperly handled, which can make them less effective or unsafe. If someone feels a medicine isn’t working, they should check dose and administration with their doctor or pharmacist before assuming the drug itself is at fault. Bottom line: one person’s lack of response to semaglutide after success with tirzepatide is interesting but anecdotal; talk with a clinician to check dose, product authenticity, and whether a different medication is a better fit.
Source: r/Semaglutide