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Someone on Reddit asked about "fat soluble vitamins" while talking about semaglutide (the weight-loss drug people also know as Ozempic or Wegovy). The post itself didn’t give much detail — just that the person was struggling and needed help — so the report here is basically a question from a user trying to figure out if they should worry about vitamins while on semaglutide. Fat-soluble vitamins are vitamins that dissolve in fat, not water. The main ones are vitamins A, D, E and K. Your body absorbs them best when there’s some dietary fat present, and your body can store them in fat tissue and the liver for later use. That storage ability is different from water-soluble vitamins (like vitamin C and the B vitamins), which your body doesn’t store much of and pees out if you have too much. The original Reddit post didn’t present a study. It sounded like someone asking for practical advice: Do I need to change how I take these vitamins now that I’m on semaglutide? There’s no evidence in that snippet that any new findings were reported. So we have to rely on what’s already known: semaglutide can slow stomach emptying and reduce appetite, which might change how much food — and therefore dietary fat — a person eats. That could, in theory, affect absorption of fat-soluble vitamins. But the post itself didn’t provide measurements, clinical data, or specific cases, so we can’t say how big any effect would be. Why this matters is simple: if someone is eating much less fat because they’re on semaglutide and not replacing fat in their meals, they could absorb less of those vitamins over time. That might matter most for people who already have low levels of certain vitamins, those on restrictive diets, older adults, or people with conditions that impair fat absorption. For most people eating a balanced diet, it may not be a big problem, but it’s something worth asking your doctor or a dietitian about if you’re on long-term semaglutide therapy. Caveats are important. The Reddit post is just a question, not evidence. We don’t know the poster’s diet, lab results, or medical history. Semaglutide is a prescription drug and should be used under medical supervision. If someone suspects vitamin deficiencies, the right step is blood tests and personalized advice. Also, because fat-soluble vitamins can build up, don’t start high-dose supplements without testing — too much can be harmful, especially vitamins A and D. Finally, if you have conditions affecting digestion or fat absorption, tell your clinician — those people may need different monitoring. Bottom line: It’s reasonable to be mindful of fat-soluble vitamins while on semaglutide, but don’t guess—get medical advice and testing before changing supplements.
Source: r/Semaglutide