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Someone on a forum said their semaglutide (the drug in Ozempic/Wegovy) seemed to stop working after a couple of years, so they tried a different brand called Tirz for a month and got good results. Then they went back to Wegovy and it didn’t seem to help anymore. Now they’re wondering whether Tirz actually lost potency, or whether something else is going on, and they’re nervous about spending money on more Tirz. Semaglutide is the active medicine in Ozempic and Wegovy. In simple terms, it acts like a natural gut hormone that tells your brain you’re full and slows how quickly food leaves your stomach. That combination reduces appetite and can lead to weight loss or help control blood sugar. Different brand names can contain the same active drug (semaglutide), but they may differ in formulation, dose strength, injection device, or storage/handling. This is an anecdote — one person’s experience — not a controlled study. From a single-month switch you can’t prove a brand’s potency changed. Several non-mutually exclusive explanations fit: dose differences (they said the Tirz month had a high dose), timing (effects can take weeks), injection technique or device differences, storage issues (semaglutide needs proper refrigeration and handling), or natural variability in how the body responds over time. Also, placebo and expectation effects matter: trying something new can feel more effective at first. There’s no rigorous data in that post to show a batch of Tirz lost effectiveness. Why this matters: many people use semaglutide drugs for weight or diabetes, and switching brands or thinking a medicine “stops working” is a common worry. If a medication seems less effective, people want to know whether to switch brands, change dose, or stop altogether. For most users the practical steps are to check dose equivalence between brands, confirm correct storage and injection technique, talk to a clinician about dose adjustment, and consider monitoring weight, appetite, and any side effects rather than relying on a single month’s experience. Caveats and risks: anecdotes can mislead. Semaglutide can have side effects like nausea, constipation, low blood sugar in people on diabetes meds, and rare but serious risks that a doctor should discuss. If the product was bought from unofficial sources, potency and safety are uncertain — counterfeit or improperly stored medication can be ineffective or unsafe. Don’t change doses or stop prescribed medications without medical advice. If you suspect a batch is bad, contact the pharmacy or manufacturer and your healthcare provider. Bottom line: One person’s month-long switch doesn’t prove Tirz lost potency — differences in dose, handling, expectation, or normal variability are more likely explanations. If you’re worried, check doses and storage, talk with your clinician, and avoid buying medicines from unreliable sources.
Source: r/Mounjaro