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Someone on an online forum asked whether it's normal to hit a weight-loss plateau after starting Wegovy (a brand of semaglutide) and having their gallbladder removed. They began Wegovy in February at about 298 pounds, lost down to 255 by mid-May, then stopped losing weight and stayed at 255 while on a 1 mg dose for two months. They also developed gallstones, had their gallbladder removed recently, paused the drug for a week around surgery, and restarted it a week after. Now they're wondering if the plateau is expected. Wegovy contains semaglutide, a medicine that copies a natural gut hormone. That hormone sends signals to your brain that reduce appetite and slow how fast your stomach empties, so people typically feel less hungry and eat less. Semaglutide is given as a weekly injection for weight management and is one of several drugs that help people lose weight by changing appetite and food intake rather than by burning extra calories directly. The report you shared is a single-person experience from a forum, not a scientific study. From clinical trials we know many people lose a lot of weight on semaglutide, especially early on, but weight loss often slows or levels off after the first few months. Plateaus are common with any weight-loss method. Surgery and temporary pauses in medication can also affect weight trends: stopping the drug briefly around surgery could blunt progress, and recovery with changes in activity or diet can influence weight too. Because this is an anecdote (one person), we can’t say how typical this exact timing is, but a few months of steady weight after rapid initial loss is within the range of what has been reported. For someone using Wegovy, the practical takeaway is that a plateau doesn’t necessarily mean the drug has stopped working. It can reflect the body settling into a new weight, changes in calorie needs as you lose weight, temporary interruptions for surgery, or shifts in diet and activity. People who care most are those taking or considering semaglutide for weight loss, especially if they have medical events like gallstones or surgery. Talking with your prescribing clinician about dose adjustments, nutritional strategies, and expectations is a good next step. Important caveats: this is not medical advice and the post you mentioned is one person’s experience. Gallstones and needing gallbladder removal are known complications that can occur during rapid weight loss; they aren’t caused only by semaglutide but by fast weight changes and other factors. Stopping and restarting the drug should be done under medical guidance. Semaglutide has side effects (nausea, stomach issues, and less commonly more serious effects) and it’s not right for everyone. Ask your doctor about whether to change dose, get nutritional support, or screen for other causes of stalled weight loss before making decisions. Bottom line: Plateaus are common after initial semaglutide-driven weight loss and after surgery; discuss your situation with your clinician to rule out medical causes and plan next steps.
Source: r/Semaglutide