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Someone who's been taking tirzepatide (brand name Mounjaro) wrote that they lost a huge amount of weight on it — about 98 pounds — and are thinking about stopping after two years. They have polycystic ovary syndrome (PCOS) and diabetes markers that were very high before treatment (A1C over 10) and are now very good (A1C 4.5). They want to know how people stop the drug without regaining weight. Tirzepatide is a prescription injectable medicine that acts like two natural gut hormones that lower appetite and help control blood sugar. Think of it as a signal your body gets that reduces hunger and slows how quickly food leaves your stomach, which makes you feel fuller for longer. It was developed as a treatment for type 2 diabetes and has been used off-label or prescribed for weight loss. It is not a vitamin or supplement — it's a powerful medical drug that changes appetite and metabolism. What this post shows is a real-world question, not a scientific study. It’s a single person reporting large weight loss and excellent blood-sugar control while on tirzepatide, and asking others for their experience stopping it. That kind of report is useful for anecdote but doesn’t prove what will happen generally. Clinical studies do show that many people lose substantial weight on tirzepatide. But other data and user reports also show weight commonly comes back when the drug is stopped unless lifestyle changes or other medical strategies are kept up. The exact amount and speed of regain vary a lot between people. Why this matters is practical. A lot of people taking tirzepatide want to know whether they can stop after reaching a target weight and keep it off. For someone with PCOS and previous high A1C, maintaining diabetes control and the metabolic benefits matters as much as the weight number. Planning a withdrawal strategy now — such as gradual dose changes, a maintenance plan with diet and exercise, close follow-up with your doctor, and possibly switching to another medication — can make the process smoother. It’s also important because stopping suddenly without a plan may lead to increased hunger and weight regain for many. There are important caveats. We don’t know from this post whether the person will regain weight or how their hormones will react. Side effects while taking tirzepatide can include nausea, diarrhea, and rarely more serious issues like pancreatitis; long-term safety questions remain under study. Stopping is not risk-free: blood sugar can rise again, and appetite often rebounds. Decisions about tapering or stopping should be made with a clinician who understands your medical history, especially with PCOS and prior high A1C. Finally, availability and approved uses vary by country and insurance coverage, so any plan should account for that. Bottom line: many people do well on tirzepatide but stopping it usually needs a plan — medical follow-up, lifestyle supports, and realistic expectations about possible weight and blood-sugar changes.
Source: r/Mounjaro