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A person posted that after starting a 1.5 mg Wegovy pill a few weeks ago, they began having bad suicidal thoughts and insomnia about 12 hours after taking the dose. They note food tastes bad now and that they have a lifelong history of binge eating and some restrictive behavior. They also say they have existing depression and PMDD (premenstrual dysphoric disorder), which can itself cause sudden suicidal thoughts, so it’s not clear whether Wegovy, the timing, or their underlying mood condition is the cause. Wegovy is the brand name for semaglutide when used for weight loss. Semaglutide is a man-made version of a hormone your gut makes that tells your brain you’re full and slows how fast your stomach empties. Doctors use it to help people lose weight by reducing appetite and making meals less rewarding. It’s given as a regular dose (often by injection, though you mentioned a pill) and can cause side effects like nausea, taste changes, and trouble sleeping for some people. What this post actually shows is a single person’s report of symptoms soon after dosing. That’s an anecdote, not a controlled study. It suggests a possible link because the timing (about 12 hours after the pill) was consistent across nights, but it cannot prove that Wegovy caused the suicidal thoughts. The person also has depression and PMDD, both known to cause sudden mood changes and suicidal thinking, which makes it much harder to attribute the symptoms to the drug. There are some clinical trial reports and safety reviews for semaglutide that list mood changes and suicidality as rare or possible concerns, but a single online report can’t tell us how common or directly caused this is. For a regular person, the practical takeaway is to take such reports seriously but cautiously. If you or someone else starts having new or worse suicidal thoughts after starting any new medication, including semaglutide/Wegovy, seek help right away—call your doctor, a crisis line, or emergency services. People who have existing mood disorders, a history of suicidal thoughts, or conditions like PMDD should tell their prescriber before starting weight-loss medications and be monitored more closely. There are important caveats. Individual reports don’t establish cause and effect. Side effects can be drug-related, related to the underlying illness, or coincidental. Semaglutide can have other side effects too (nausea, GI upset, sleep issues) and isn’t suitable for everyone; prescribing guidelines and regulatory approvals vary by country and individual health history. If you’re the person posting this or someone around them, don’t stop or change medication without talking to a healthcare professional, but do get immediate help if suicidal thoughts are present or increasing. Bottom line: This report raises a red flag worth taking seriously, but it doesn’t prove Wegovy caused the suicidal thoughts — anyone experiencing these symptoms should get urgent medical attention and discuss risks with their prescriber.
Source: r/Semaglutide