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A reader who’s been taking Ozempic (the drug semaglutide) wrote in worried that after three months of good weight loss, their hunger and sense of fullness have come back. They started at 102 kg, went down to 88.5 kg, and had been on a low dose for the first month then a moderate dose for the next eight weeks. For the last week to ten days they’re feeling more hunger and less of the “full” feeling that helped them eat less. They want to know if the medicine has stopped working. Semaglutide is the active ingredient in medicines sold as Ozempic and Wegovy. In plain terms, it acts like a natural gut hormone that talks to your brain about food. It makes you feel less hungry and helps you feel full sooner, and it also slows how fast your stomach empties. Doctors often start people on a low dose and slowly increase it to reduce side effects. It’s not a stimulant — it’s more like a long-lasting signal that nudges appetite down over time. What this anecdote shows is exactly that: real people can have strong early results on semaglutide. Losing 13.5 kg in about three months is a substantial change and fits with how the drug helps reduce calorie intake. But single-person stories can’t prove a permanent breakdown of effect. There are a few common patterns seen in people on these drugs: appetite can fluctuate, weight loss often slows after an initial drop, and your body can adapt so the dramatic early feeling of “I’m never hungry” becomes less intense. The snippet doesn’t report blood tests, other medications, changes in routine, or whether the person plans to increase dose, so we can’t say for sure what’s driving the change. Why it matters is practical: if you’re using semaglutide for weight management, you should expect some ups and downs. Early weight loss and strong appetite suppression are common; later, progress can slow and hunger can return somewhat. That doesn’t necessarily mean the drug has “stopped working.” It may mean your dose needs adjustment, your body is adapting, or lifestyle factors (sleep, stress, exercise, other foods or medications) are affecting appetite. Anyone relying on the medication for diabetes or obesity should keep regular appointments with their prescriber so they can decide if the dose needs to be changed or if other strategies should be added. There are important caveats and risks. Semaglutide has side effects like nausea, constipation, or rarely more serious issues, and it’s not safe for everyone (for example, people with a history of certain thyroid cancers are usually advised against it). Stopping the drug often leads to weight regain, so changes should be done under a doctor’s guidance. Also, short-term hunger returning does not necessarily indicate a medical emergency, but you should check in with your clinician before changing dose or stopping. Finally, one person’s experience is not a study; bigger, controlled trials are what tell us how these drugs work on average. Bottom line: a return of some hunger after a strong initial response is common and doesn’t automatically mean semaglutide has stopped working, but it’s a good reason to discuss dose, expectations, and lifestyle factors with your healthcare provider.
Source: r/Semaglutide