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A person shared that they started taking Rybelsus (an oral diabetes/weight-loss drug) on March 20 and lost a lot of weight quickly at first — from 297 to 266 pounds by early May. But for the last three weeks their weight has stayed stuck around 266–268. They recently increased their dose from 3 mg to 7 mg and after a few days noticed no change: hunger and cravings came back, they ate a lot at a buffet, and they’re wondering if the pill has become “weaker” and whether they should switch to an injectable like Ozempic. Rybelsus is the brand name for oral semaglutide. In simple terms, semaglutide is a drug that acts like a natural gut hormone that helps reduce appetite and slow stomach emptying. That’s why people often feel less hungry and eat less on it. Rybelsus is the pill form; drugs like Ozempic are the same active substance given as injections. Different doses and delivery methods can affect how strong the effect feels. What this personal report shows is a common pattern: an early, fairly rapid weight drop followed by a plateau and then a return of appetite. This is an anecdote — one person’s experience — not a controlled study. The timing (loss, plateau, dose increase, no immediate effect) fits what we know about biology: appetite and metabolism adapt over time, and it can take days to weeks after a dose change to see a clear difference. Also, individual responses vary a lot. A three-day window after upping the dose is probably too short to judge whether the higher dose will help. There’s no evidence here that the drug “became weaker”; it’s more likely normal variation, adaptation, or other factors like stress, sleep, or extra calorie-rich events (buffets). Why it matters: if you’re using semaglutide to lose weight or control appetite, it’s useful to know that plateaus and cravings can happen and don’t always mean the medication has stopped working. Doctors commonly adjust dose, check adherence (are you taking it exactly as prescribed?), and discuss lifestyle supports. Some people do switch to injectables or different medications, but that decision should be based on medical evaluation, not a single episode of regained appetite. Caveats and risks: semaglutide can cause nausea, stomach upset, and in rare cases more serious problems (pancreatitis, gallbladder issues), and it’s not right for everyone. Rybelsus needs to be taken on an empty stomach with little water and then wait before eating; taking it incorrectly can reduce absorption. Increasing dose or switching to injectables should be done under a doctor’s guidance. Also, anecdotal accounts don’t replace clinical data — if weight stops changing or side effects appear, talk to your prescriber to review dosing, timing, other medications, and overall plan. Bottom line: plateaus and return of appetite are common; give a dose change time, check how you’re taking the drug, and discuss options with your clinician rather than assuming the pill has become weaker.
Source: r/Semaglutide