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Someone who was taking Wegovy (a brand name for the drug semaglutide) says the medicine worked great at first but then stopped working. They began on a low dose, felt full quickly, and could eat much less. Over time that effect faded and their weight went back to near where they started. They’ve now increased the dose to 1 mg but don’t feel any change yet and are worried higher doses might not help. Semaglutide is the active ingredient in Wegovy (a prescription weight-loss drug) and Ozempic (used for diabetes and sometimes for weight). In plain terms, it acts like a natural gut hormone that tells your brain “you’re full” and slows how fast your stomach empties. It doesn’t burn fat directly; instead it reduces appetite and helps people eat less. Doctors typically start with a low dose and slowly raise it to reduce side effects and find the dose that works long-term. What this person reports is an individual, real-world experience — essentially an anecdote, not a controlled study. Clinical trials of semaglutide showed that many people lose significant weight when using it and following lifestyle guidance, but not everyone responds the same way. Some people see strong appetite suppression that persists; others notice the effect lessening over time, or need higher doses. The snippet doesn’t give numbers about how many people stop responding or how often higher doses restore the effect, so we can’t generalize from this single story. Why it matters is practical: if you or someone you know is trying semaglutide for weight loss, it’s useful to know that responses vary. Some people may need dose adjustments, different behavioral supports, or a check for other causes of increased hunger, like stress, sleep problems, or other medications. Clinicians sometimes switch drugs, change dose schedules, or add counseling and nutrition support when appetite suppression fades. Knowing that losing the initial effect isn’t unheard of can help set expectations and prompt a discussion with your doctor rather than giving up. There are important caveats. This is one person’s report, not proof that higher doses won’t work broadly. Semaglutide comes with side effects — nausea, vomiting, constipation, and, less commonly, pancreatitis or gallbladder problems — and long-term effects are still being studied. It’s prescription-only; you shouldn’t change your dose or stop/start it without medical advice. People with a personal or family history of certain thyroid cancers or with specific medical conditions shouldn’t take it. Finally, weight often rebounds if the medication is stopped, so plans for long-term management matter. Bottom line: some people lose the appetite-suppressing benefit of semaglutide over time, and a higher dose helps some but not all — if it happens to you, talk with your clinician about options rather than guessing on your own.
Source: r/Semaglutide