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A woman who used Mounjaro (tirzepatide) says she dropped from about 90 kg (198 lb) to 50 kg (110 lb) in roughly eight months, largely because the drug made her much less hungry. She combined the medication with exercise and didn’t feel like she was starving. Now she's concerned about keeping the weight off once the drug is stopped or tapered, and is asking whether other people have been able to maintain similar results. Tirzepatide is a prescription medication that acts like two natural gut hormones that help control appetite and blood sugar. Think of it as a signal to your brain that you’re full and as something that slows how quickly your stomach empties. It’s sold under the brand name Mounjaro for diabetes and is being used off-label or in similar forms for weight loss because it reduces hunger and leads to steady, often large, weight drops in many people. The research we have shows that tirzepatide can produce major weight loss for many users, often far more than older drugs. Most of the strong data come from clinical trials of people who kept taking the drug for many months to a few years. Those studies generally show big losses while people are on the medication. But when trials include follow-ups after stopping the drug, weight regain is common—people often regain some or much of the weight they lost. That pattern—lose more while on the drug, regain after stopping—has also been seen with other appetite-suppressing medications, and patient stories echo that same concern. Why this matters is simple: for anyone taking Mounjaro to lose weight, the long-term question isn’t just how fast or how much you can lose, but how you’ll keep it off. If the drug is doing the heavy lifting by suppressing appetite, stopping it without a plan can let hunger return and weight creep back. People who care about long-term health—those with diabetes, high blood pressure, joint pain, or just wanting lasting lifestyle change—need to think about the plan for maintenance, not only the initial drop. There are important caveats. Side effects can include nausea, stomach upset, and rarely more serious problems; it’s prescription-only and should be managed by a doctor. The evidence on long-term maintenance after stopping the drug is limited, so it’s uncertain whether everyone can keep the weight off without continued medication. Stopping suddenly is more likely to lead to weight regain than tapering with a structured behavior plan. And these drugs aren’t suitable for everyone—pregnant people, certain medical conditions, or those without medical supervision shouldn’t use them. Bottom line: Mounjaro can make losing weight much easier, but keeping it off usually takes more than the drug alone—sustained habits, medical follow-up, and a plan for what happens if the medication is reduced or stopped.
Source: r/Mounjaro