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Someone on a forum asked whether anyone else is taking the ADHD drugs lisdexamfetamine (Elvanse) and dexamfetamine (Amfexa) together while also starting Wegovy Oral (the oral form of semaglutide). They report taking the ADHD meds for years and began Wegovy Oral about two weeks ago, and they’re noticing something has changed since then. The post is a question asking for others’ experiences, not a scientific report. Lisdexamfetamine (Elvanse) is a prescription stimulant used for ADHD. It’s a “prodrug,” which means it becomes the active drug (dexamfetamine) inside your body after digestion. Dexamfetamine is a stimulant that raises levels of certain brain chemicals to help with attention and focus. Wegovy Oral contains semaglutide, which is a type of medicine that acts like a natural gut hormone to reduce appetite and slow how fast your stomach empties. Semaglutide is used for weight management and is related to the injectable drugs people often call Ozempic or Wegovy. This post is an anecdote — a single person describing their medications and a new experience after starting Wegovy Oral. It’s not a controlled study, and we don’t know exactly what change they noticed because the snippet cuts off. From clinical knowledge, semaglutide can cause stomach-related side effects (nausea, vomiting, slower gastric emptying) that might affect how fast other oral drugs are absorbed. That could potentially change the timing or intensity of stimulant effects for someone taking lisdexamfetamine and extra dexamfetamine doses. But the forum post itself does not prove a cause-and-effect link; it’s a report that could prompt further questions or careful monitoring. Why this matters: lots of people take multiple prescriptions, and interactions or combined effects can change how a drug feels or works. If semaglutide slows stomach emptying, someone who relies on a stimulant to kick in at predictable times might notice delays or stronger peaks later. Anyone taking stimulants for ADHD who starts a medication that affects digestion or appetite might want to pay attention to timing of doses, symptoms, sleep, blood pressure, or heart rate. This is relevant to patients and prescribers who want to keep treatment effective and safe. Important caveats: this is not medical advice and not a study. We can’t say for sure what’s causing the change without more details or medical review. Semaglutide can cause nausea, appetite loss, and gastrointestinal upset. Stimulants can raise heart rate and blood pressure, reduce appetite, and affect sleep. Combining medicines that affect appetite and digestion doesn’t usually create a direct chemical “interaction,” but it can alter how fast pills are absorbed or change side effects. Anyone noticing new or worrying symptoms after adding a drug should consult their prescribing clinician or pharmacist. Don’t stop or change doses on your own. Bottom line: a person reported changes after starting Wegovy Oral while on lisdexamfetamine and dexamfetamine, which could plausibly relate to semaglutide’s effects on the gut, but it’s an anecdote—check with your doctor or pharmacist for personalized guidance.
Source: r/Semaglutide