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Someone on a forum posted that they’re two weeks into taking semaglutide at the usual starter dose (0.25 mg) and they’re experiencing terrible nausea and vomiting — vomiting every day for two weeks, six times in one day — and yet they haven’t lost any weight, despite barely keeping down a meal. They’re asking if this is normal and what to expect. Semaglutide is the drug in brand-name medicines like Ozempic and Wegovy. In plain terms, it’s a man-made version of a hormone your gut makes after eating that helps tell your brain you’re full and slows how fast your stomach empties. Doctors use it to help control blood sugar in diabetes and, at higher doses, to help people lose weight. It’s given as a once-weekly injection and doses are usually started low and slowly increased to reduce side effects. What the evidence and clinical experience show is that nausea is a common early side effect with semaglutide. In clinical trials, many people had stomach upset, nausea, and sometimes vomiting, especially when treatment begins or when the dose is increased. For most people these symptoms are mild to moderate and settle over days to a few weeks as the body adjusts. Severe, prolonged vomiting like the example you quoted is less common but not unheard of. Trials also show weight loss tends to take a few weeks to become noticeable; it’s not guaranteed right away and can be delayed if someone is unable to eat regularly because of nausea. Why this matters is practical: if you’re starting semaglutide or considering it, expect some stomach side effects at first and plan for ways to manage them — smaller bland meals, staying hydrated, and talking with your doctor about anti-nausea options. If the nausea is so bad that you’re vomiting daily or unable to keep fluids down, that’s clinically important because it can lead to dehydration, nutrient loss, and other problems. People taking semaglutide for weight loss or diabetes want to know whether the drug will help them, but severe side effects can interfere with any benefit. Caveats and risks: semaglutide is a prescription medication and should be used under medical supervision. Don’t assume everyone reacts the same way — some people tolerate it fine, others don’t. If vomiting is severe or persistent, seek medical advice promptly; your clinician may slow the dose increase, pause treatment, switch drugs, or prescribe anti-nausea medicine. There are also other, rarer risks discussed with prescribers (for example, a history of certain thyroid tumors or pancreatitis can change the risk/benefit), so medical history matters. Finally, forum posts are individual experiences — they’re useful signals but not the same as controlled studies. Bottom line: nausea is a known early effect of semaglutide and often gets better, but daily vomiting and inability to keep food or fluids down are serious and deserve quick medical follow-up.
Source: r/Semaglutide