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A person shared a health story: in mid-2023 they had very high blood sugar control numbers (A1C of 11.1, which is well into the diabetes range) and weighed about 215 pounds. They tried Ozempic briefly, then switched to Mounjaro, and also took metformin plus Crestor for cholesterol. They didn’t change their diet much but started doing more workout classes. By early 2025 their A1C and cholesterol were back in the normal range, so they stopped metformin and Crestor and are asking for advice. Ozempic and Mounjaro are brand-name injectable medications used to treat type 2 diabetes. In plain terms, they act like hormones your body uses to control blood sugar and appetite. Ozempic’s active ingredient (semaglutide) mimics a gut hormone that tells the brain you’re full and slows stomach emptying. Mounjaro (tirzepatide) works on two similar hormone pathways and tends to lower blood sugar and can cut appetite even more. Metformin is a long-established pill that lowers blood sugar mainly by reducing the liver’s glucose output. Crestor is a cholesterol-lowering drug (a statin) that reduces risk of heart disease by lowering LDL cholesterol. What this post actually shows is an individual’s experience — an anecdote, not a clinical trial. The person had a very high A1C and used medication changes plus more exercise, and over about 18 months their numbers normalized. That suggests the drugs and increased activity likely played a role, but we can’t say which was most important or what would happen for others. Anecdotes don’t tell us how common this outcome is, how much weight changed, or whether lifestyle or the medications did the heavy lifting. There’s also no detail on dosages, other health conditions, or whether bloodwork was repeated under consistent conditions. Why this matters to regular people: it’s an example of how modern diabetes drugs, combined with exercise, can strongly improve blood sugar and cholesterol for some people. If you or someone you know has high A1C or bad cholesterol, this kind of story may be encouraging because it shows improvement is possible. It also highlights that people sometimes switch medications (like from Ozempic to Mounjaro) when one option isn’t ideal or doesn’t work as expected. But it’s a reminder to work with a clinician — changes in meds and stopping prescriptions should be guided by blood tests and medical advice. Important caveats and risks: this is a single-person report. Stopping drugs like metformin or a statin without a doctor’s approval can be risky; bloodwork should be monitored after changes. GLP-1 drugs (Ozempic, semaglutide) and dual agonists (tirzepatide) can cause side effects such as nausea, diarrhea, and rarely more serious issues; not everyone loses weight or normalizes A1C. Statins and metformin have their own side effects and reasons to continue them even when numbers look better. Also, underlying causes of improved labs (measurement differences, temporary changes) aren’t excluded here. Bottom line: this is a hopeful personal story of big lab improvements after medication changes and more exercise, but it’s just one case — anyone thinking of switching or stopping diabetes or cholesterol meds should discuss it carefully with their doctor and keep regular testing.
Source: r/Mounjaro