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You went back on semaglutide hoping to lose the 10 pounds you regained, but after eight months back on it you haven’t lost any weight and you’re feeling discouraged. Previously, when you used it for about 10 months, you did lose roughly 50 pounds and felt much better, especially with symptoms of PCOS (polycystic ovary syndrome). You stopped because the drug became too expensive, gained back about 10 pounds while off it, and then restarted expecting to shed that weight — which hasn’t happened so far. Semaglutide is the active ingredient in drugs you may have heard of, like Ozempic and Wegovy. In plain terms, it acts like a natural gut hormone that tells the brain “you’re full” and slows how fast food leaves your stomach. That combination tends to reduce appetite and calorie intake, which is why many people lose weight on it. It’s a prescription medication, and its effects can depend a lot on dose, timing, and individual biology. From your short report we don’t have formal study data — it’s a single-person experience, not a clinical trial. Your past experience (50-pound loss in 10 months) shows semaglutide can have a large effect for some people. But your recent eight-month run with no weight loss shows that responses can change over time. That could be because of dose differences, changes in diet or activity, how your body adapts, or other health factors like PCOS that affect hormones and weight. We can’t say which without more details or medical assessment. This matters because it highlights that medications like semaglutide aren’t a guaranteed, permanent fix for everyone. If you had great results before and now see none, it’s reasonable to check a few things: whether your current dose matches what you used before, whether you’re taking it exactly as prescribed, and whether other factors (stress, sleep, other meds, or metabolic changes) have shifted. People with PCOS or other hormonal conditions may notice more variability and often need a tailored plan combining medication with diet, activity, and medical follow-up. There are important caveats. Side effects can include nausea, gastrointestinal upset, and rarely more serious issues; long-term effects are still being studied. Cost and access are real barriers, as you experienced. Also, weight regain after stopping is common, which is why ongoing plans and support matter. If a medication stops working as it once did, a doctor can check for other causes, consider dose adjustments, or suggest alternative strategies. Don’t adjust or stop prescriptions on your own. Bottom line: Semaglutide helped you dramatically before, but medicines can change in how well they work for a given person over time — talk with your prescriber to review dose, other factors, and next steps rather than giving up hope.
Source: r/Semaglutide