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Someone in an online post said they were just prescribed two peptides — tesamorelin and ipamorelin — and asked about dosing. They listed the concentrations they received (tesamorelin 4 mg per mL, ipamorelin 1 mg per mL) and wrote that they are injecting 0.17 mL Monday through Friday, with no doses on weekends. They tried to calculate how much of each peptide that dose delivers but cut the math off in the snippet you shared. Tesamorelin and ipamorelin are both short chains of amino acids (peptides) that act on the body's growth hormone system, but they work in different ways. Tesamorelin is a synthetic version of a naturally occurring signal that tells the brain to make more growth hormone–releasing hormone, which ultimately raises levels of growth hormone. It’s approved in some places for specific medical uses, like reducing excess belly fat in certain people with HIV. Ipamorelin is a peptide that mimics part of the natural hormone ghrelin (sometimes called the “hunger hormone”) to directly stimulate the pituitary gland to release growth hormone. Think of tesamorelin as flipping the upstream switch, and ipamorelin as nudging the pituitary itself. What the post shows is just a person sharing their prescribed concentrations and frequency. There’s no formal study here — it’s an individual’s dosing schedule, not clinical trial data. From the numbers given you can calculate amounts: 0.17 mL of a 4 mg/mL solution is about 0.68 mg of tesamorelin per injection, and 0.17 mL of a 1 mg/mL ipamorelin solution is about 0.17 mg per injection. With five injections a week that’s roughly 3.4 mg/week of tesamorelin and 0.85 mg/week of ipamorelin. But the snippet doesn’t say what the clinic intended those totals to accomplish, nor do we know the patient’s medical background, exact instructions, or monitoring plan. Why someone might be prescribed these: both peptides can be used when there’s a medical reason to boost growth-hormone activity — for example, muscle wasting, certain metabolic problems, or specific approved indications like the HIV-related condition I mentioned. Some clinics and people also use them for anti-aging, body composition, or recovery goals, although evidence for those uses varies. If you’re considering this kind of treatment, the practical takeaway is to confirm the math with your prescriber, make sure you understand the treatment goals, and ask about how progress and side effects will be monitored. Important caveats: these are prescription treatments and should be used only under medical supervision. Side effects can include joint pain, swelling, increased blood sugar, and other hormonal changes. Tesamorelin is approved for specific uses; ipamorelin is less commonly approved and is often used off-label. Doses and schedules matter a lot, and combining peptides can change effects and risks. Pregnant people, those with certain cancers, or uncontrolled medical conditions should not use growth-hormone–stimulating drugs without clear medical guidance. If anything feels wrong while using them, contact your clinician promptly. Bottom line: the post lists a plausible dosing plan that works out to small milligram amounts per injection, but you should verify the calculations and clinical intent with the prescribing clinic and get clear monitoring and safety guidance.
Source: r/Peptides