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Someone on Reddit who’s been taking Mounjaro (tirzepatide) said they’re feeling much colder than coworkers this winter and that losing weight has messed with their body temperature. They wrote that Uniqlo Heattech thermal undershirts have helped them stay comfortable when layered under regular work clothes. The post is just a personal tip from one person, not a scientific study. Tirzepatide, sold as Mounjaro, is a medication used to treat type 2 diabetes and for weight loss in some people. It’s a kind of peptide drug — that just means it’s a small protein-like molecule designed to act like natural signals in the body. Tirzepatide works on hormones that affect appetite and blood sugar; by making you eat less and lose weight, it can indirectly change how your body handles heat. What the Reddit note actually shows is an individual’s experience: they noticed lower body temperature after losing weight on Mounjaro and found that thermal underwear helped. This is anecdote — one person’s report — not controlled research. There are published studies showing people who lose a lot of weight often feel colder because less body fat and changes in metabolism reduce heat production and insulation, but the post itself doesn’t measure temperature, compare groups, or prove tirzepatide is the direct cause. Why that matters: if you’re taking Mounjaro or another weight-loss drug and suddenly feel colder, this is a useful and practical reminder that weight loss can change how you experience temperature. Simple fixes like warmer clothing, layering, or insulated undershirts can make daily life easier without changing your treatment. Employers and coworkers might not realize this is common, so it can help to know it’s a normal, manageable effect. A few cautions: feeling colder after losing weight is common, but if you have symptoms like persistent numbness, dizziness, fainting, or an unusually low core temperature, see a clinician. Don’t assume the drug is the only cause — thyroid problems, anemia, poor circulation, or other conditions can also make you cold. Thermal shirts are harmless, but any change in medication or dosing should be discussed with your prescriber. Also remember one Reddit post doesn’t replace medical advice or scientific evidence. Bottom line: people on tirzepatide may feel colder as they lose weight, and practical solutions like Heattech layers can help — but check with a doctor if you have worrying symptoms.
Source: r/Mounjaro