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A person posted that they used to drink a lot of coffee — multiple shots of espresso plus other caffeinated drinks — and noticed their feet were swelling. After starting Mounjaro (a prescription diabetes/weight-loss medication), they cut their coffee from about 5–6 shots a day down to 1 (around 3 shots), and they say the swelling improved. The note is brief and anecdotal: it’s one person reporting a change they noticed while using Mounjaro and changing their coffee habit. Mounjaro is the brand name for tirzepatide, a prescription drug originally developed for diabetes and now also used for weight loss. It’s not coffee or a stimulant. It works by copying (mimicking) certain natural gut hormones that help control blood sugar and appetite. Those hormones tell your brain to feel less hungry and slow how fast your stomach empties. The drug is given by injection under a doctor’s supervision, and it can cause people to eat less and lose weight. The report here mixes two things: starting Mounjaro and cutting back on coffee. The post suggests that reducing the amount of espresso helped the person’s foot swelling. But this is just one person’s experience, not a controlled study. We don’t know whether the swelling was actually caused by caffeine, by something else (like fluid retention from diet or medication), or whether Mounjaro changed the swelling directly or indirectly (for example, by reducing appetite, changing salt intake, or causing weight loss). There’s no data on how big the change was beyond the poster saying their feet improved after they limited coffee. Why this might matter to a regular person: if you drink a lot of caffeine and notice symptoms like swelling, jitteriness, sleep trouble, or digestive changes, it’s reasonable to try cutting back and see if you feel better. Also, people starting medications like Mounjaro should track any changes in symptoms and habits, because drugs can change appetite, fluid balance, digestion, and activity levels — all of which can affect things like swelling. If you’re concerned about swelling or other symptoms, it’s worth mentioning to your prescriber so they can check for causes or interactions. Important caveats: this is an anecdote, not proof. Caffeine can cause different effects in different people, but it’s not commonly known to directly cause peripheral swelling (swollen feet) in otherwise healthy people; other causes should be ruled out. Mounjaro has side effects (nausea, diarrhea, low blood sugar risk in people on diabetes meds, and others) and should be used only under medical supervision. Don’t assume stopping or starting medications on the basis of a single online post. If you have unexplained swelling, sudden weight changes, or other worrying symptoms, see a healthcare professional for evaluation rather than relying on anecdotes. Bottom line: One person says cutting way back on espresso after starting Mounjaro seemed to reduce their foot swelling, but it’s an individual report and doesn’t prove what caused the swelling.
Source: r/Mounjaro