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Someone on a forum said they started using semaglutide (they bought it from a pharmacy) and after three weekly injections at the lowest dose they haven’t noticed any weight change or even the common side effects people talk about, like nausea or less appetite. They expected little at this dose, but were surprised to feel nothing at all after three doses and wondered if that was normal. Semaglutide is the active drug in well-known prescriptions like Ozempic and Wegovy. In plain terms, it acts like a hormone your gut makes after you eat that tells your brain you’re full and slows how fast your stomach empties. That combination tends to reduce appetite and can lead to weight loss over weeks to months. The drug is prescribed at carefully increased doses for weight management or diabetes, and the effect depends a lot on dose, time, and how a person responds. What this anecdote actually shows is just one person’s early experience at the smallest starting dose. Clinical trials and prescribing guides make clear that semaglutide’s effects build up over time and with higher doses; most people don’t see big weight changes after just one or a few injections. Also, not everyone gets noticeable side effects like nausea — some people barely feel anything. This single report doesn’t prove the drug won’t work for them later, but it also doesn’t tell us anything about long-term outcomes because it’s just one short-term, self-reported case. Why it matters: if you’re considering semaglutide for weight loss or blood sugar control, this highlights two things. First, don’t expect dramatic results after a couple of doses — it usually takes weeks to months and often requires dose escalation under a doctor’s supervision. Second, absence of immediate side effects doesn’t mean the drug isn’t working; it may just mean you’re a milder responder or still on too low a dose. People who want predictable timelines and monitoring should use it through a clinician who can advise on dose changes and track progress. Important caveats: buying prescription semaglutide outside a doctor’s plan or using it without medical oversight has risks. Dose schedules, interactions with other medications, and side effects (nausea, vomiting, stomach issues, and more rarely changes in heart rate or pancreatitis concerns) need medical context. The long-term safety profile for weight use is still being studied even though there’s good trial data; individual responses vary. If someone feels unwell, or if they’re pregnant, planning pregnancy, have certain medical conditions, or take other medications, they should consult a healthcare professional before continuing. Bottom line: Feeling nothing after three small doses isn’t unusual, but effective, safe use of semaglutide typically takes time, proper dosing, and medical supervision.
Source: r/Semaglutide