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Someone on an online forum says they’re on the 25 mg Wegovy tablet and the appetite suppression is stronger than they want. They’ve been titrating up over several months and now find it hard to eat enough before runs and workouts. They’re asking whether taking the pill every other day instead of daily might help. Wegovy is the brand name for semaglutide in a tablet form used for weight management. Semaglutide is a drug that acts like a natural gut hormone that tells your brain you’re full and slows stomach emptying, so you feel less hungry and eat less. It was developed as a once-daily tablet (or once-weekly injection in other versions) to lower appetite and help people lose weight when used with diet and exercise. The post is a personal report, not a clinical trial. It describes a single person’s experience of feeling “too suppressed” — low appetite that makes it hard to fuel exercise. That kind of effect is known for semaglutide: many people report reduced hunger, and some struggle to eat enough, especially around exercise. But one person’s report can’t tell us how common this is or whether every-other-day dosing would work. Clinical studies test specific doses and schedules; changing the schedule can change blood levels of the drug and hasn’t been proven safe or effective unless a doctor recommends it. Why this matters: if you use Wegovy (or semaglutide) and you’re physically active, feeling overly suppressed can hurt performance, recovery, and overall energy. People who exercise a lot need to take in calories and protein at certain times, so persistent nausea or lack of appetite can be a real problem. If appetite suppression is interfering with daily life or workouts, it’s worth talking to your prescribing clinician about options — adjusting dose, timing, meal strategies, or switching formulations — rather than experimenting on your own. Important caveats: you should not change the prescribed dosing schedule without medical advice. Semaglutide levels in the body follow the approved regimen; skipping days can lead to unpredictable effects, withdrawal of benefit, or side effects. Common side effects include nausea, upset stomach, and low appetite; less common but serious risks (reported with this drug class) include pancreatitis and, in animal studies, rare thyroid tumors — discuss these with your provider. If you’re underweight, pregnant, trying to become pregnant, or have certain medical conditions, semaglutide may not be appropriate. Bottom line: feeling over-suppressed on Wegovy is a known issue and worth addressing, but don’t self-adjust to every-other-day dosing — talk to your clinician about safe ways to manage appetite, dosing, or alternative strategies.
Source: r/Semaglutide