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A person on an online forum says they lost about 50 kg (110 lb) over the past year while using Mounjaro (a prescription drug) and now feel stuck eating roughly 1,300 calories a day without continuing to lose weight. They began at about 137 kg (302 lb) and are now around 87 kg (192 lb). They report that early on they were eating about 2,000 calories and losing several kilos each month, but weight loss has slowed as they got lighter and their calorie intake dropped. Mounjaro is the brand name for tirzepatide, a medicine that acts like gut hormones that tell your brain you’re full and slow how fast your stomach empties. Think of it as a stronger version of drugs like Ozempic and Wegovy, which use a similar trick. These drugs are given by injection and were developed for diabetes and weight loss because they lower appetite and can reduce how much people eat without them trying to starve themselves. The report isn’t a scientific study — it’s one person’s account on a forum — but it echoes a common pattern doctors and researchers see. When people start these medications at higher weights, appetite drops and weight falls quickly. As the person becomes lighter, their body needs fewer calories, and weight loss naturally slows. Hitting a “plateau” where 1,300 calories no longer produces loss is plausible. Clinical trials of tirzepatide show big average weight losses, but trial participants have close medical supervision and structured programs. Individual experiences vary a lot. This matters because many people hoping to use these drugs expect steady, linear weight loss. That’s not how biology usually works. Your body adapts: as you lose weight you burn fewer calories at rest and during activity, and appetite signals and energy needs change. For someone who has already lost a lot, continued progress often requires adjusting activity, calorie timing, meal composition, or medication dose with medical guidance. Anyone using these medicines should work with a clinician or a dietitian to set realistic goals and strategies for the next phase. Important caveats: this is an anecdote, not proof of a drug failure. Side effects of tirzepatide/Mounjaro can include nausea, diarrhea, stomach pain, and, more rarely, pancreatitis or gallbladder issues. These drugs are prescription-only and not appropriate for everyone — people with certain medical histories (like a personal or family history of specific thyroid tumors) should avoid them. Long-term effects and the best ways to maintain weight loss are still being studied. Don’t change doses or stop medication without talking to your healthcare provider. Bottom line: Rapid early weight loss on Mounjaro is common, but plateaus are also common as your body adapts — if you’re stuck, the next step is a careful plan with a clinician rather than trying extreme calorie cuts on your own.
Source: r/Mounjaro