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Someone on an online forum wrote that after about 18 months on GLP-1 drugs (first Ozempic, now Mounjaro) they’ve lost 75 pounds and see it in the mirror and in smaller shirts and dresses. But their pants size barely changed — only one size — because their belly hasn’t shrunk as much as other parts of their body. They asked if others have the same issue and how to fix it. GLP-1 drugs are a class of medicines originally developed to treat type 2 diabetes. Brand names you might have heard are Ozempic and Wegovy (both contain the drug semaglutide) and Mounjaro (tirzepatide, which also hits another related pathway). In plain terms, these drugs mimic a hormone that tells your brain you’re not as hungry and makes your stomach empty more slowly. That usually leads to eating less and losing weight. They don’t magically target fat in one spot; they change overall appetite and metabolism. What this person describes is an anecdote — a single person’s experience posted on a forum. That kind of story can be useful to understand how real people feel, but it’s not a controlled study. Clinical trials of GLP-1 medicines show substantial average weight loss across groups, but people vary a lot in where they lose fat first. Visceral fat (around organs, in the belly) can be stubborn or sometimes responds more slowly than subcutaneous fat (under the skin) that you see on arms, face, and hips. Also factors like genetics, sex, age, hormones, and exercise habits influence body-shape changes. The poster’s 75-pound loss is a large change, and seeing different rates of change in different body parts is common. Why this matters: if you’re taking these drugs or thinking about them for weight loss, expect overall weight loss but not necessarily dramatic, even changes in clothing sizes across the board. Many people notice their upper body, face, or hips change sooner than their waist. That can affect self-image and how clothes fit, which matters for daily life and motivation. If someone wants more belly reduction, combining medication with targeted lifestyle changes — such as resistance training to build core and overall muscle mass, improving sleep, and managing stress — may help, though spot-reduction of fat is not possible. Important caveats: this is one person’s account, not proof of how everyone will respond. GLP-1 drugs have side effects (nausea, constipation, rarely more serious problems) and aren’t appropriate for everyone. Mounjaro and Ozempic are prescription medicines; dosage and use should be supervised by a clinician. Expect variability in results, and don’t assume a fix like diet tweaks or exercise will instantly change where your body loses fat. If persistent belly fat is a concern, talk to a healthcare provider to review medical causes (like hormones or medications), adjust strategies safely, and set realistic expectations. Bottom line: GLP-1s can cause big overall weight loss, but it’s normal for belly fat to shrink more slowly than other areas, and individual responses vary.
Source: r/Mounjaro