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Someone started taking semaglutide (the active drug behind Ozempic/Wegovy) in October 2024, used it regularly, and lost a lot of weight before their September 2025 wedding. They went from a high weight of about 210 pounds down to 143 by the wedding day, feeling great then. Right after the wedding they entered a deep depression and are asking how to get back on track. Semaglutide is a medicine that acts like a natural hormone your gut makes after you eat. That hormone tells your brain you’re full and slows how fast your stomach empties, so you eat less and feel satisfied longer. It’s given as a once-weekly injection for weight management and for diabetes when used at different doses. People often notice steady weight loss and reduced appetite while they’re on it. The story you shared is a personal report, not a controlled study. It’s an anecdote: one person’s experience over about a year of use. The clear finding is that semaglutide helped them lose a lot of weight leading up to the wedding. The rest — the depression that followed — is a report of what happened after stopping or around the time of life changes. We don’t know whether their mood shift was caused by stopping the drug, by post-event letdown (a common emotional dip after a big goal is achieved), by changes in lifestyle or eating, or by something else. Anecdotes are useful for raising questions but can’t prove cause-and-effect. Why this matters: lots of people use semaglutide for weight loss and want to know what happens after major life events or when they stop. If someone loses a lot of weight and then experiences mood changes, fatigue, or weight regain, it affects relationships, health, and everyday life. This is relevant to people thinking about starting semaglutide, those planning a short-term course, and clinicians who help with transitions off the drug or with mental-health support after big life events. Important caveats: this is one person’s story, not a study, so don’t assume the same will happen to everyone. Semaglutide can cause side effects like nausea, constipation, low blood sugar (especially if you’re on diabetes meds), and in some people it can change mood or appetite in ways that affect mental health. Stopping it abruptly can lead to returning appetite and weight regain for many people. Depression after a big goal is common and may need psychological support. Anyone with severe mood symptoms should talk to a doctor or therapist right away. Decisions about starting, stopping, or changing dosing should be made with a healthcare provider. Bottom line: semaglutide can drive significant weight loss for many, but emotional ups and downs or appetite rebound after finishing treatment are real possibilities — get medical and mental-health support when you’re planning major changes.
Source: r/Semaglutide