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A person in their late 70s who has been using Ozempic/Wegovy for about two and a half years shared that they lost roughly 65 pounds but hit a plateau around 155 pounds nine months ago. They recently increased their weekly dose from 1.7 mg to 2.4 mg hoping to nudge their weight down to about 145 pounds. After a couple of weeks they briefly dropped to 152, but then their weight climbed back up to about 159–161 despite continuing the injections. They’re worried they might be stuck at this higher weight. Ozempic and Wegovy both contain semaglutide, a lab-made version of a natural gut hormone that helps control appetite. In simple terms, it tells your brain you’re full sooner and slows how fast your stomach empties, so you feel satisfied on less food. Semaglutide is prescribed at different doses for diabetes (Ozempic) and for weight loss (Wegovy), but the active molecule is the same; doctors adjust the dose to balance benefits and side effects. What this person’s story shows is a very common real-world pattern: initial weight loss on semaglutide, then a plateau, and sometimes small rebounds even after raising the dose. This is an anecdote — one individual’s experience — not a controlled study. Clinical trials have shown many people lose substantial weight on semaglutide, but individual responses vary. Some people continue to lose after a dose increase, others stabilize, and some regain a bit. Changes of a few pounds over weeks are common and don’t prove the drug has stopped working. Why this matters is practical. If you or someone you know is using these drugs, it’s useful to expect plateaus and small rebounds rather than steady losses forever. Age, prior weight history, activity level, diet, muscle mass, and how long you’ve been on the medication all affect outcomes. For older adults, losing too much too fast can be risky, so a modest target and careful monitoring by a clinician are reasonable. A dose bump can help some people, but it’s not a guaranteed fix. There are important caveats. This is a single-person report, not evidence that most people will regain weight after increasing dose. Semaglutide can cause side effects like nausea, stomach upset, and in rare cases more serious issues; it’s prescription-only for a reason. Doctors often combine the drug with lifestyle changes and follow-up. Stopping the medication usually leads to weight regain, so long-term plans matter. Anyone worried about dose, side effects, or unexpected weight changes should discuss it with their prescribing clinician rather than changing treatment on their own. Bottom line: plateaus and small rebounds on semaglutide are common; a dose increase might help but isn’t guaranteed, so check with your doctor and focus on a sustainable plan.
Source: r/Semaglutide