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Someone on an online forum asked for advice because their weight loss stalled after starting Mounjaro. They began the drug in July 2025 and lost 55 pounds, mostly during the first eight months. For the past six months their weight has barely budged while they’ve been taking a 10 mg dose, and they’re asking if others have had the same experience and what to do next. Mounjaro is the brand name for tirzepatide, a medicine that acts like two natural gut hormones that help control appetite and blood sugar. In plain terms, it makes you feel less hungry and can slow how quickly your stomach empties, so you eat less and feel fuller longer. Doctors prescribe it for people with type 2 diabetes and for weight management in many cases. It’s given as a regular injection and is part of the same family of drugs people talk about when they mention Ozempic or Wegovy, though it works slightly differently. What the person’s post shows is a common pattern with these drugs: big early weight loss followed by a slowdown or plateau. Clinical studies and many patient reports confirm that the largest losses often happen soon after starting or increasing the dose, and progress can then slow as the body adjusts. The snippet doesn’t say whether their doctor checked other factors like diet, activity, sleep, stress, or medical issues — all of which affect weight. It also doesn’t say whether they’ve tried changing dose, timing, or adding structured lifestyle interventions, so we can’t know what options they’ve already explored. Why this matters: if you or someone you know is using Mounjaro or a similar drug, it’s useful to expect that plateaus can happen and aren’t necessarily a sign that the medication has “stopped working.” Plateaus often mean it’s time to reassess the whole plan — talk with a healthcare provider about dose adjustments, nutrition strategy, strength training to preserve muscle, and addressing sleep or medications that can affect weight. For people using the drug under medical supervision, this is an opportunity to fine-tune treatment rather than give up. Important caveats: tirzepatide and similar drugs can have side effects like nausea, diarrhea, or low blood sugar (especially if you take diabetes pills too). They aren’t suitable for everyone, and dose increases should only be done with a doctor. Long-term safety and what happens when people stop the drug are still active areas of research, so expectations about permanent weight loss should be cautious. If weight loss stalls, don’t assume it’s purely the drug’s fault — get medical checks for thyroid issues, medications, or other conditions that can affect weight. Bottom line: plateaus are common with Mounjaro; talk with your clinician about adjusting dose or your overall plan rather than quitting, and investigate other health or lifestyle factors that could be holding progress back.
Source: r/Mounjaro